Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

dc.contributor.authorSweeney-Reed, Catherine M.en_US
dc.contributor.authorZaehle, Tinoen_US
dc.contributor.authorVoges, Juergenen_US
dc.contributor.authorSchmitt, Friedhelm C.en_US
dc.contributor.authorBuentjen, Larsen_US
dc.contributor.authorBorchardt, Violaen_US
dc.contributor.authorWalter, Martinen_US
dc.contributor.authorHinrichs, Hermannen_US
dc.contributor.authorHeinze, Hans-Jochenen_US
dc.contributor.authorRugg, Michael D.en_US
dc.contributor.authorKnight, Robert T.en_US
dc.contributor.utdAuthorRugg, Michael D.en_US
dc.date.accessioned2018-09-24T15:41:22Z
dc.date.available2018-09-24T15:41:22Z
dc.date.created2017-07-20
dc.descriptionIncludes supplementary materialen_US
dc.description.abstractCross-frequency coupling (CFC) between slow and fast brain rhythms, in the form of phase-amplitude coupling (PAC), is proposed to enable the coordination of neural oscillatory activity required for cognitive processing. PAC has been identified in the neocortex and mesial temporal regions, varying according to the cognitive task being performed and also at rest. PAC has also been observed in the anterior thalamic nucleus (ATN) during memory processing. The thalamus is active during the resting state and has been proposed to be involved in switching between task-free cognitive states such as rest, in which attention is internally-focused, and externally-focused cognitive states, in which an individual engages with environmental stimuli. It is unknown whether PAC is an ongoing phenomenon during the resting state in the ATN, which is modulated during different cognitive states, or whether it only arises during the performance of specific tasks. We analyzed electrophysiological recordings of ATN activity during rest from seven patients who received thalamic electrodes implanted for treatment of pharmacoresistant focal epilepsy. PAC was identified between theta (4-6 Hz) phase and high frequency band (80-150 Hz) amplitude during rest in all seven patients, which diminished during engagement in tasks involving an external focus of attention. The findings are consistent with the proposal that theta-gamma coupling in the ATN is an ongoing phenomenon, which is modulated by task performance.en_US
dc.description.departmentSchool of Behavioral and Brain Sciencesen_US
dc.description.departmentCenter for Vital Longevityen_US
dc.identifier.bibliographicCitationSweeney-Reed, Catherine M., Tino Zaehle, Juergen Voges, Friedhelm C. Schmitt, et al. 2017. "Anterior thalamic high frequency band activity is coupled with theta oscillations at rest." Frontiers in Human Neuroscience 11, doi:10.3389/fnhum.2017.00358en_US
dc.identifier.issn1662-5161en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6124
dc.identifier.volume11en_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.urihttp://dx.doi.org/10.3389/fnhum.2017.00358en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authors.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalFrontiers in Human Neuroscienceen_US
dc.subjectAnterior Thalamic Nucleien_US
dc.subjectMental Processesen_US
dc.subjectNeocortexen_US
dc.subjectElectrophysiologyen_US
dc.subjectEpilepsies, Partialen_US
dc.subjectElectroencephalographyen_US
dc.subjectThalamusen_US
dc.titleAnterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Resten_US
dc.typeTexten_US
dc.type.genrearticleen_US

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