Comparison of Neural Activity in Chronic Pain Patients during Tonic and Burst Spinal Cord Stimulation Using Fluorodeoxyglucose Positron Emission Tomography

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dc.contributor.ORCID0000-0002-9906-1836 (Vanneste, S)
dc.contributor.authorYearwood, T.
dc.contributor.authorDe Ridder, D.
dc.contributor.authorYoo, Hye Bin
dc.contributor.authorFalowski, S.
dc.contributor.authorVenkatesan, L.
dc.contributor.authorTing To, W.
dc.contributor.authorVanneste, Sven
dc.contributor.utdAuthorYoo, Hye Bin
dc.contributor.utdAuthorVanneste, Sven
dc.date.accessioned2020-01-29T20:38:28Z
dc.date.available2020-01-29T20:38:28Z
dc.date.issued2019-04-30
dc.descriptionDue to copyright restrictions full text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).
dc.description.abstractObjective: Burst spinal cord stimulation (SCS) is a novel stimulation paradigm that seems to provide better pain relief compared to the classic tonic SCS with minimal paresthesia sensation. Based on source localized electroencephalography and clinical data, it has been proposed that burst stimulation as defined by Dirk De Ridder exerts this greater effect by not only modulating the lateral and the descending pain-inhibitory pathways (similar to tonic SCS) but also modulating the medial pain pathway, which encodes the affective, motivational aspects of pain. Material and Methods: The current study evaluates the supraspinal differences between burst and tonic stimulation with another functional imaging technique, namely fluorodeoxyglucose positron emission tomography (FGD-PET) scanning, in seven patients, who underwent both burst and tonic SCS, to confirm this notion of medial pain pathway modulation. Results: The results of the current FGD-PET study show that burst stimulation, in contrast to tonic stimulation, indeed modulates the dorsal anterior cingulate cortex (i.e., medial pain pathway) more than tonic stimulation. Discussion: Our data suggest an inherent difference in the central neural mechanisms during burst and tonic stimulation, which could potentially alter the patient's perception of pain. ©2019 International Neuromodulation Society
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.identifier.bibliographicCitationYearwood, T., D. De Ridder, H. B. Yoo, S. Falowski, et al. 2019. "Comparison of Neural Activity in Chronic Pain Patients During Tonic and Burst Spinal Cord Stimulation Using Fluorodeoxyglucose Positron Emission Tomography." Neuromodulation 23(1): 56-63, doi: 10.1111/ner.12960
dc.identifier.issn1094-7159
dc.identifier.issue1
dc.identifier.urihttp://dx.doi.org/10.1111/ner.12960
dc.identifier.urihttps://hdl.handle.net/10735.1/7200
dc.identifier.volume23
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.rights©2019 International Neuromodulation Society
dc.source.journalNeuromodulation
dc.subjectGyrus Cinguli
dc.subjectPain
dc.subjectPositron-Emission Tomography
dc.subjectSpinal Cord Stimulation
dc.subjectFluorodeoxyglucose
dc.titleComparison of Neural Activity in Chronic Pain Patients during Tonic and Burst Spinal Cord Stimulation Using Fluorodeoxyglucose Positron Emission Tomography
dc.type.genrearticle

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