Closed-Loop Neuromodulation Restores Network Connectivity and Motor Control After Spinal Cord Injury

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dc.contributor.authorGanzer, Patrick D.
dc.contributor.authorDarrow, Michael J.
dc.contributor.authorMeyers, Eric C.
dc.contributor.authorSolorzano, Bleyda R.
dc.contributor.authorRuiz, Andrea D.
dc.contributor.authorRobertson, Nicole M.
dc.contributor.authorAdcock, Katherine S.
dc.contributor.authorJames, Justin T.
dc.contributor.authorJeong, Han S.
dc.contributor.authorBecker, April M.
dc.contributor.authorGoldberg, Mark P.
dc.contributor.authorPruitt, David T.
dc.contributor.authorHays, Seth A.
dc.contributor.authorKilgard, Michael P.
dc.contributor.authorRennaker, Robert L. II
dc.contributor.utdAuthorGanzer, Patrick D.
dc.contributor.utdAuthorDarrow, Michael J.
dc.contributor.utdAuthorMeyers, Eric C.
dc.contributor.utdAuthorSolorzano, Bleyda R.
dc.contributor.utdAuthorRuiz, Andrea D.
dc.contributor.utdAuthorRobertson, Nicole M.
dc.contributor.utdAuthorAdcock, Katherine S.
dc.contributor.utdAuthorJames, Justin T.
dc.contributor.utdAuthorJeong, Han S.
dc.contributor.utdAuthorPruitt, David T.
dc.contributor.utdAuthorHays, Seth A.
dc.contributor.utdAuthorKilgard, Michael P.
dc.contributor.utdAuthorRennaker, Robert L. II
dc.date.accessioned2019-05-31T20:21:42Z
dc.date.available2019-05-31T20:21:42Z
dc.date.created2018-03-13
dc.descriptionIncludes supplementary material
dc.description.abstractRecovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentTexas Biomedical Device Center
dc.identifier.bibliographicCitationGanzer, Patrick D., Michael J. Darrow, Eric C. Meyers, Bleyda R. Solorzano, et al. 2018. "Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury." eLife 7, doi:10.7554/eLife.32058
dc.identifier.issn2050-084X
dc.identifier.urihttps://hdl.handle.net/10735.1/6526
dc.identifier.volume7
dc.language.isoen
dc.publishereLife Sciences Publications Ltd
dc.relation.urihttp://dx.doi.org/10.7554/eLife.32058
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2018 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.journaleLife
dc.subjectVagus Nerve Stimulation
dc.subjectPlasticity
dc.subjectStroke
dc.subjectAdult
dc.subjectRats
dc.subjectNeurons
dc.subjectMotor Cortex
dc.subjectSpinal cord--Wounds and injuries
dc.subjectRehabilitation
dc.subjectTrauma, Nervous System
dc.titleClosed-Loop Neuromodulation Restores Network Connectivity and Motor Control After Spinal Cord Injury
dc.type.genrearticle

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