Long-Term Effects of Marijuana Use on the Brain

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dc.contributor.ISNI0000 0001 3618 6298 (Filbey, FM)en_US
dc.contributor.ResIDJ-5163-2014 (Filbey, FM)en_US
dc.contributor.authorFilbey, Francesca M.en_US
dc.contributor.authorAslan, Sinaen_US
dc.contributor.authorCalhoun, Vince D.en_US
dc.contributor.authorSpence, Jeffrey S.en_US
dc.contributor.authorDamaraju, Eswaren_US
dc.contributor.authorCaprihan, Arvinden_US
dc.contributor.authorSegall, Judithen_US
dc.contributor.utdAuthorFilbey, Francesca M.
dc.contributor.utdAuthorAslan, Sina
dc.contributor.utdAuthorSpence, Jeffrey S.
dc.date.accessioned2015-04-01T18:30:13Z
dc.date.available2015-04-01T18:30:13Z
dc.date.created2014-11-25
dc.description.abstractQuestions surrounding the effects of chronic marijuana use on brain structure continue to increase. To date, however, findings remain inconclusive. In this comprehensive study that aimed to characterize brain alterations associated with chronic marijuana use, we measured gray matter (GM) volume via structural MRI across the whole brain by using voxel-based morphology, synchrony among abnormal GM regions during resting state via functional connectivity MRI, and white matter integrity (i.e., structural connectivity) between the abnormal GM regions via diffusion tensor imaging in 48 marijuana users and 62 age- and sex-matched nonusing controls. The results showed that compared with controls, marijuana users had significantly less bilateral orbitofrontal gyri volume, higher functional connectivity in the orbitofrontal cortex (OFC) network, and higher structural connectivity in tracts that innervate the OFC (forceps minor) as measured by fractional anisotropy (FA). Increased OFC functional connectivity in marijuana users was associated with earlier age of onset. Lastly, a quadratic trend was observed suggesting that the FA of the forceps minor tract initially increased following regular marijuana use but decreased with protracted regular use. This pattern may indicate differential effects of initial and chronic marijuana use that may reflect complex neuroadaptive processes in response to marijuana use. Despite the observed age of onset effects, longitudinal studies are needed to determine causality of these effects.en_US
dc.description.sponsorship"This work was supported by National Institute on Drug Abuse Grant K01 DA021632."en_US
dc.identifier.bibliographicCitationFilbey, Francesca M., Sina Aslan, Vince D. Calhoun, Jeffrey S. Spence, et al. 2014. "Long-term effects of marijuana use on the brain." Proceedings of the National Academy of Sciences of the United States of America 111(47): 16913-16918.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.issue47en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/4420
dc.identifier.volume111en_US
dc.language.isoenen_US
dc.publisherNatl Acad Sciencesen_US
dc.relation.urihttp://dx.doi.org/10.1073/pnas.1415297111en_US
dc.rights©2014 The National Academy of Sciences of the United States of America.en_US
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subjectMarijuana--Physiological effecten_US
dc.subjectDiffusion tensor imagingen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectPrefrontal Cortexen_US
dc.titleLong-Term Effects of Marijuana Use on the Brainen_US
dc.typeTexten_US
dc.type.genrearticleen_US

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Filbey, Francesca M.