Novel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment

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dc.contributor.authorQuiram, Gina
dc.contributor.authorMontagner, Francisco
dc.contributor.authorPalmer, Kelli L.
dc.contributor.authorStefan, Mihaela C.
dc.contributor.authorWashington, Katherine E.
dc.contributor.authorRodrigues, Danieli C.
dc.contributor.utdAuthorQuiram, Gina
dc.contributor.utdAuthorPalmer, Kelli L.
dc.contributor.utdAuthorStefan, Mihaela C.
dc.contributor.utdAuthorWashington, Katherine E.
dc.contributor.utdAuthorRodrigues, Danieli C.
dc.date.accessioned2019-06-28T19:15:37Z
dc.date.available2019-06-28T19:15:37Z
dc.date.created2018-04-17
dc.description.abstractPersistence of microorganisms in dentinal tubules after root canal chemo-mechanical preparation has been well documented. The complex anatomy of the root canal and dentinal buffering ability make delivery of antimicrobial agents difficult. This work explores the use of a novel trilayered nanoparticle (TNP) drug delivery system that encapsulates chlorhexidine digluconate, which is aimed at improving the disinfection of the root canal system. Chlorhexidine digluconate was encapsulated inside polymeric self-assembled TNPs. These were self-assembled through water-in-oil emulsion from poly(ethylene glycol)-b-poly(lactic acid) (PEG-b-PLA), a di-block copolymer, with one hydrophilic segment and another hydrophobic. The resulting TNPs were physicochemically characterized and their antimicrobial effectiveness was evaluated against Enterococcus faecalis using a broth inhibition method. The hydrophilic interior of the TNPs successfully entrapped chlorhexidine digluconate. The resulti ng TNPs had particle size ranging from 140–295 nm, with adequate encapsulation efficiency, and maintained inhibition of bacteria over
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.sponsorshipNSF nos. (CHE-1126177, CHE-1609880, CHE-1566059); Welch Foundation (AT-1740),
dc.identifier.bibliographicCitationQuiram, Gina, Francisco Montagner, Kelli L. Palmer, Mihaela C. Stefan, et al. 2018. "Novel chlorhexidine-loaded polymeric nanoparticles for root canal treatment." Journal of Functional Biomaterials 9(2): 29, doi:10.3390/jfb9020029
dc.identifier.issue2
dc.identifier.urihttps://hdl.handle.net/10735.1/6644
dc.identifier.volume9
dc.relation.urihttps://dx.doi.org/10.3390/jfb9020029
dc.rightsCC BY 4.0 (Attribution)
dc.rights©2018 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.source.journalJournal of Functional Biomaterials
dc.subjectChlorhexidine
dc.subjectDentin
dc.subjectPolymeric
dc.subjectPolyethylene glycol
dc.subjectPolylactic acid
dc.titleNovel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment
dc.type.genrearticle

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