Synthesis and Characterization of Chlorhexidine-Containing Polymeric Trilayered Nanoparticle for Root Canal Treatment

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dc.contributor.advisorRodrigues, Danieli C.
dc.creatorQuiram, Gina J.
dc.date.accessioned2017-06-26T11:53:13Z
dc.date.available2017-06-26T11:53:13Z
dc.date.created2017-05
dc.date.issued2017-05
dc.date.submittedMay 2017
dc.date.updated2017-06-26T11:53:13Z
dc.description.abstractDisinfection during a root canal treatment is limited due to anatomical complexities. Better carrier systems of antimicrobial agents are needed to ensure efficient bacteria eradication. Block copolymer nanoparticles have great potential as drug delivery vehicles because of their small size that allows accumulation of drug at target sites and ease of synthesis. This study sought to use block copolymer nanoparticles to improve drug bioavailability, direct drug distribution to a precise site, and sustain release after endodontic procedures. To accomplish this chlorhexidine-containing nanoparticles were designed to steadily release the drug. The drug chlorhexidine was encapsulated in poly(ethylene glycol)–block–poly(L-lactide) (PEG–b–PLA) to synthesize bilayer and trilayered nanoparticles. These polymeric nanoparticles were characterized for size, morphology, and drug loading proficiency. In conclusion, these nanoparticles were found to be small enough to penetrate dentin tubules, dispersed well in a hydrogel matrix carrier system, and enhanced bacterial inhibition over longer periods of time.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/10735.1/5419
dc.language.isoen
dc.rightsCopyright ©2017 is held by the author. Digital access to this material is made possible by the Eugene McDermott Library. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.subjectNanoparticles
dc.subjectChlorhexidine
dc.subjectPolymeric drug delivery systems
dc.subjectColloids in medicine
dc.subjectDentin
dc.subjectEndodontics
dc.subjectRoot canal therapy
dc.subjectPolyvinyl alcohol
dc.subjectDisinfection and disinfectants
dc.subjectAnti-infective agents
dc.subjectBlock copolymers
dc.titleSynthesis and Characterization of Chlorhexidine-Containing Polymeric Trilayered Nanoparticle for Root Canal Treatment
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentBiomedical Engineering
thesis.degree.grantorUniversity of Texas at Dallas
thesis.degree.levelMasters
thesis.degree.nameMS

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