A Typical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment

dc.contributor.ISNI0000 0003 8601 2186 (Evans, JL)
dc.contributor.VIAF306453126 (Evans, JL)
dc.contributor.authorBrown, Timothy T.en_US
dc.contributor.authorErhart, Matthewen_US
dc.contributor.authorAvesar, Danielen_US
dc.contributor.authorDale, Anders M.en_US
dc.contributor.authorHalgren, Ericen_US
dc.contributor.authorEvans, Julia L.en_US
dc.date.accessioned2014-09-10T19:06:40Z
dc.date.available2014-09-10T19:06:40Z
dc.date.created2014-02-14
dc.description.abstractIndividuals with a diagnosis of specific language impairment (SLI) show abnormal spoken language occurring alongside normal non-verbal abilities. Behaviorally, people with SLI exhibit diverse profiles of impairment involving phonological, grammatical, syntactic, and semantic aspects of language. In this study, we used a multimodal neuroimaging technique called anatomically constrained magnetoencephalography (aMEG) to measure the dynamic functional brain organization of an adolescent with SLI. Using single-subject statistical maps of cortical activity, we compared this patient to a sibling and to a cohort of typically developing subjects during the performance of tasks designed to evoke semantic representations of concrete objects. Localized patterns of brain activity within the language impaired patient showed marked differences from the typical functional organization, with significant engagement of right hemisphere heteromodal cortical regions generally homotopic to the left hemisphere areas that usually show the greatest activity for such tasks. Functional neuroanatomical differences were evident at early sensoriperceptual processing stages and continued through later cognitive stages, observed specifically at latencies typically associated with semantic encoding operations. Our findings show with real-time temporal specificity evidence for an atypical right hemisphere specialization for the representation of concrete entities, independent of verbal motor demands. More broadly, our results demonstrate the feasibility and potential utility of using aMEG to characterize individual patient differences in the dynamic functional organization of the brain.en_US
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke (P50 NS022343); National Institute on Deafness and Other Communication Disorders (R01 DC005650)en_US
dc.identifier.bibliographicCitationBrown, Timothy T., Matthew Erhart, Daniel Avesar, Anders M. Dale, et al. 2014. "A typical right hemisphere specialization for object representations in an adolescent with specific language impairment." Frontiers In Human Neuroscience 8(82): 1-11.en_US
dc.identifier.issn1662-5161en_US
dc.identifier.issue82en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3998
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.urihttp://dx.doi.org/10.3389/fnhum.2014.00082en_US
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2014 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.source.journalFrontiers in Human Neuroscienceen_US
dc.subjectSpecific language impairment in childrenen_US
dc.subjectCerebral dominanceen_US
dc.subjectBrain organizationen_US
dc.subjectMagnetoencephalographyen_US
dc.subjectLanguage Developmenten_US
dc.titleA Typical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairmenten_US
dc.typeTexten_US
dc.type.genrearticleen_US

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