Vanneste, SvenAlsalman, OlaDe Ridder, Dirk2020-08-042020-08-042019-01-090270-6474http://dx.doi.org/10.1523/JNEUROSCI.0966-18.2018https://hdl.handle.net/10735.1/8768Auditory phantom percepts such as tinnitus are associated with auditory deafferentation. The idea is that auditory deafferentation limits the amount of information the brain can acquire to make sense of the world. Because of this, auditory deafferentation increases the uncertainty of the auditory environment. To minimize uncertainty, the deafferented brain will attempt to obtain or fill in the missing information. A proposed multiphase compensation model suggests two distinct types of bottom-up related tinnitus: an auditory cortex related tinnitus and a parahippocampal cortex related tinnitus. The weakness of this model is that it cannot explain why some people without hearing loss develop tinnitus, whereas conversely others with hearing loss do not develop tinnitus. In this human study, we provide evidence for a top-down type of tinnitus associated with a deficient noise-cancelling mechanism. A total of 72 participants (age: 40.96 ± 7.67 years; males: 48; females: 24) were recruited for this study. We demonstrate that top-down related tinnitus is related to a change in the pregenual anterior cingulate cortex that corresponds to increased activity in the auditory cortex. This is in accordance with the idea that tinnitus can have different generators as proposed in a recent model that suggests that different compensation mechanisms at a cortical level can be linked to phantom percepts.en©2019 The AuthorsAuditory cortexDeafnessHippocampus (Brain)TinnitusArrhythmiaSoundAgeTomographyNeurosciencesGyrus CinguliarticleVanneste, Sven, Ola Alsalman, and Dirk De Ridder. 2019. "Top-down and Bottom-up Regulated Auditory Phantom Perception." Journal of Neuroscience 39(2): 364-378, doi: 10.1523/JNEUROSCI.0966-18.2018392