Luzuriaga, Michael A.Benjamin, Candace E.Gaertner, Michael W.Lee, HamiltonHerbert, Fabian C.Mallick, SniptaGassensmith, Jeremiah J.2020-02-202020-02-202019-05-111061-0278http://dx.doi.org/10.1080/10610278.2019.1616089https://hdl.handle.net/10735.1/7290Due to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is not available. UTD affiliates may be able to acquire a copy through Interlibrary Loan by using the link to UTD ILL.Drug delivery using metal-organic frameworks (MOF) has elicited interest in their biocompatibility; however, few studies have been conducted on their stability in common buffers, cell media, and blood proteins. In particular, the use of ZIF-8, a MOF interconnected by Zn and methylimidazole, has been frequently employed. In this study, we tested single crystals of ZIF-8 with common laboratory buffers, cell media, and serum, and noted several issues. Buffers containing phosphate and bicarbonate alter the appearance and composition of ZIF-8; however, these buffers do not appear to cause cargo to leak out even when the ZIF-8 itself is displaced by phosphates. On the other hand, serum dissolves ZIF-8, causing premature cargo release. Our results show that ZIF-8 undergoes surface chemistry changes that may affect the interpretation of cellular uptake and cargo release data. On the other hand, it provides a rational explanation as to how ZIF-8 neatly dissolves in vivo. ©2019 Informa UK Limited, trading as Taylor & Francis Group.en©2019 Informa UK Ltd.BiocompatibilityImidazoles (Zeolitic)ZincMethylimidazoleZIF-8articleLuzuriaga, M. A., C. E. Benjamin, M. W. Gaertner, H. Lee, et al. 2019. "ZIF-8 degrades in cell media, serum, and some—but not all—common laboratory buffers." Supramolecular Chemistry 31(8): 485-490, doi: 10.1080/10610278.2019.1616089318