Wang, X.Greer, Joshua S.Dimitrov, I. E.Pezeshk, P.Chhabra, A.Madhuranthakam, A. J.2019-08-072019-08-072018-09-151053-1807https://hdl.handle.net/10735.1/6776Full text access from Treasures at UT Dallas is restricted to current UTD affiliates (use the provided Link to Article).BACKGROUND: The 3D short tau inversion recovery (STIR) sequence is routinely used in clinical MRI to achieve robust fat suppression. However, the performance of the commonly used adiabatic inversion pulse, hyperbolic secant (HS), is compromised in challenging areas with increased B₀ and B₁ inhomogeneities, such as brachial plexus at 3T. PURPOSE: To demonstrate the frequency offset corrected inversion (FOCI) pulse as an efficient fat suppression STIR pulse with increased robustness to B₀ and B₁ inhomogeneities at 3T, compared to the HS pulse. STUDY TYPE: Prospective. SUBJECTS/PHANTOM: Initial evaluation was performed in phantoms and one healthy volunteer by varying the B₁ field, while subsequent comparison was performed in three healthy volunteers and five patients without varying the B₁. FIELD STRENGTH/SEQUENCE: 3T; 3D TSE-STIR with HS and FOCI pulses. ASSESSMENT: Brachial plexus images were qualitatively evaluated by two musculoskeletal radiologists independently using a four-point grading scale for fat suppression, shading artifacts, and nerve visualization. STATISTICAL TEST: The Wilcoxon signed-rank test with P < 0.05 was considered statistically significant. RESULTS: Simulations and phantom experiments demonstrated broader bandwidth (2.5 kHz vs. 0.83 kHz, increased B₀ robustness) at the same adiabatic threshold and lower adiabatic threshold (5 μT vs. 7 μT at 3.5 ppm, increased B₁ robustness) at the same bandwidth with the FOCI pulse compared to the HS pulse. With increased bandwidth, the FOCI pulse achieved robust fat suppression even at 50% of maximum B₁ strength, while the HS pulse required > 75% of maximum B₁ strength. Compared to the standard 3D TSE-STIR with HS pulse, the FOCI pulse achieved uniform fat suppression (P < 0.05), better nerve visualization (P < 0.05), and minimal shading artifacts (P < 0.01) in brachial plexus at 3T. DATA CONCLUSION: The FOCI pulse has increased robustness to B₀ and B₁ inhomogeneities, compared to the HS LEVEL OF EVIDENCE: 1. TECHNICAL EFFICACY: Stage 1.en©2018 International Society for Magnetic Resonance in MedicineBrachial plexusFat--SuppressionNerves, PeripheralMagnetic resonance imagingarticleWang, X., J. S. Greer, I. E. Dimitrov, P. Pezeshk, et al. 2018. "Frequency Offset Corrected Inversion Pulse for B₀ and B₁ Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus." Journal of Magnetic Resonance Imaging 48(4): 1104-1111, doi:10.1002/jmri.26021484