Khairalseed, MawiaJaved, KulsoomJashkaran, G.Kim, J. -WParker, K. J.Hoyt, Kenneth2020-02-172020-02-172019-04-170278-4297http://dx.doi.org/10.1002/jum.14806https://hdl.handle.net/10735.1/7271Due to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is not available. UTD affiliates may be able to acquire a copy by using the link below to contact university Interlibrary Loan.Objective—H-scan imaging is a new ultrasound technique used to visualize the relative size of acoustic scatterers. The purpose of this study was to evaluate the use of H-scan ultrasound imaging for monitoring early tumor response to neoadjuvant treatment using a preclinical breast cancer animal model. Methods—Real-time H-scan ultrasound imaging was implemented on a programmable ultrasound scanner (Vantage 256; Verasonics Inc., Kirkland, WA) equipped with an L11-4v transducer. Bioluminescence and H-scan ultrasound was used to image luciferase-positive breast cancer–bearing mice at baseline and at 24, 48, and 168 hours after administration of a single dose of neoadjuvant (paclitaxel) or sham treatment. Animals were euthanized at 48 or 168 hours, and tumors underwent histologic processing to identify cancer cell proliferation and apoptosis. Results—Baseline H-scan ultrasound images of control and therapy group tumors were comparable, but the latter exhibited significant changes over the 7-day study (P 0.40, P < .04). Conclusion—Preliminary preclinical results suggest that H-scan ultrasound imaging is a new and promising tissue characterization modality. H-scan ultrasound imaging may provide prognostic value when monitoring early tumor response to neoadjuvant treatment. © 2018 by the American Institute of Ultrasound in Medicine.en©2018 American Institute of Ultrasound in MedicineApoptosisCancerDiagnostic ultrasonic imagingNeoadjuvant TherapyCell DeathCell ProliferationMammalsTumorsBreast--CancerarticleKhairalseed, M., K. Javed, G. Jashkaran, J. -W Kim, et al. 2019. "Monitoring early breast cancer response to neoadjuvant therapy using H-scan ultrasound imaging: Preliminary preclinical results." Journal of Ultrasound In Medicine 38(5): 1259-1268, doi: 10.1002/jum.14806385