Zhang, ShanrongZhou, K.Huang, G.Takahashi, MasayaSherry, A. DeanGao, Jinming2014-08-292014-08-292013-05-262013-05-261359-7345http://hdl.handle.net/10735.1/3947In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.en©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.Chemical Exchange Saturation Transfer (CEST)Magnetic resonance imagingBlock copolymersMicellesArticleZhang, S., K. Zhou, G. Huang, M. Takahashi, et al. 2013. "A novel class of polymeric pH-responsive MRI CEST agents." Chemical Communications 49(57): 6418-642049576418