Song, Jae-JinKim, KyungsooSunwoo, WoongsangMertens, GrietVan de Heyning, PaulDe Ridder, DirkVanneste, SvenLee, Sang-YoupPark, Kyung-JoonChoi, HongsooChoi, Ji-Woong2018-09-242018-09-242017-05-181662-5161http://hdl.handle.net/10735.1/6120Includes Corrigendum.The mechanism of tinnitus suppression after cochlear implantation (CI) in single-sided deafness (SSD) is not fully understood. In this regard, by comparing pre-and post-CI quantitative electroencephalography (qEEG), we explored cortical changes relevant to tinnitus improvement. In SSD patients who underwent CI, qEEG data were collected: (1) before CI, (2) 6 months post-operatively with CI-on, and (3) 30 min after CI-off and source-localized cortical activity/functional connectivity analyses were performed. Compared to the pre-operative baseline, the CI-on condition demonstrated significantly decreased activity in the right auditory-and orbitofrontal cortices (OFC) for the delta frequency band as well as decreased connectivity between the auditory cortex/posterior cingulate cortex for the delta/beta2 bands. Meanwhile, compared to the CI-off condition, the CI-on condition displayed decreased activity in the right auditory cortices/OFC for the delta band, and in bilateral auditory cortices, left inferior frontal cortex/OFC for the gamma band. However, qEEG analyses showed no significant differences between the CI-off and baseline conditions. CI induced overall decreased cortical activity and functional connectivity. However, judging from no differences between the CI-off and baseline conditions, CI-induced cortical activity and functional connectivity changes are not by cortical plastic changes, but by dynamic peripheral reafferentation.enCC BY 4.0 (Attribution)©2017 The Authorshttp://creativecommons.org/licenses/by/4.0/Prefrontal CortexHearing Loss, UnilateralPersistent Vegetative StateAuditory CortexBrainPlasticityTinnitusCochlear ImplantationElectroencephalographyTextSong, Jae-Jin, Kyungsoo Kim, Woongsang Sunwoo, Griet Mertens, et al. 2017. "A quantitative electroencephalography study on cochlear implant-induced cortical changes in single-sided deafness with tinnitus." Frontiers in Human Neuroscience 11, doi:10.3389/fnhum.2017.0021011