Yu, Mengxiao
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/7029
Mengxiao Yu is a Research Assistant Professor in Dr. Jie Zheng's lab working in the area of noninvasive Kidney functional imaging.
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Item Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles(Wiley-VCH Verlag, 2019-05-14) Peng, Chuanqi; Xu, Jing; Yu, Mengxiao; Ning, Xuhui; Huang, Yingyu; Du, Bujie; Hernandez, E.; Kapur, P.; Hsieh, J. -T; Zheng, Jie; 0000-0001-8546-1882 (Zheng, J); 22147423113244881679 (Zheng, J); Peng, Chuanqi; Xu, Jing; Yu, Mengxiao; Ning, Xuhui; Huang, Yingyu; Du, Bujie; Zheng, JiePrecise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting-clearance and permeation-retention paradoxes in the anticancer-drug delivery. Herein, we systematically investigated how renal-clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal-clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal-clearable AuNPs also accelerated body clearance of off-target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim