Maguire, Mandy J.
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/4927
Dr. Mandy Maguire is an Associate Professor of Communication Sciences and Disorders. Dr. Maguire's research integrates three different areas of psychology: neurocognitive development, language acquisition and conceptual development. She also serves as the head of the Developmental Neurolinguistics Laboratory
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Item Theta and Alpha Alterations in Amnestic Mild Cognitive Impairment in Semantic Go/NoGo Tasks(Frontiers) Nguyen, Lydia T.; Mudar, Raksha A.; Chiang, Hsueh-Sheng; Schneider, Julie M.; Maguire, Mandy J.; Kraut, Michael A.; Hart, John, Jr.; 0000 0003 5139 1227 (Maguire, MJ); 0000 0000 5491 4773 (Hart, J); Chiang, Hsueh-Sheng; Schneider, Julie M.; Maguire, Mandy J.; Hart, John, Jr.Growing evidence suggests that cognitive control processes are impaired in amnestic mild cognitive impairment (aMCI); however the nature of these alterations needs further examination. The current study examined differences in electroencephalographic theta and alpha power related to cognitive control processes involving response execution and response inhibition in 22 individuals with aMCI and 22 age-, sex-, and education-matched cognitively normal controls. Two Go/NoGo tasks involving semantic categorization were used. In the basic categorization task, Go/NoGo responses were made based on exemplars of a single car (Go) and a single dog (NoGo). In the superordinate categorization task, responses were made based on multiple exemplars of objects (Go) and animals (NoGo). Behavioral data showed that the aMCI group had more false alarms during the NoGo trials compared to controls. The EEG data revealed between group differences related to response type in theta (4-7 Hz) and low-frequency alpha (8-10 Hz) power. In particular, the aMCI group differed from controls in theta power during the NoGo trials at frontal and parietal electrodes, and in low-frequency alpha power during Go trials at parietal electrodes. These results suggest that alterations in theta power converge with behavioral deterioration in response inhibition, whereas alterations in low-frequency alpha power appear to precede behavioral changes in response execution. Both behavioral and electrophysiological correlates combined provide a more comprehensive characterization of cognitive control deficits in aMCI.Item Developmental Differences in Beta and Theta Power During Sentence Processing(Elsevier Ltd) Schneider, Julie M.; Abel, A. D.; Ogiela, D. A.; Middleton, Anna E.; Maguire, Mandy J.; 0000 0003 5139 1227 (Maguire, MJ)Although very young children process ongoing language quickly and effortlessly, research indicates that they continue to improve and mature in their language skills through adolescence. This prolonged development may be related to differing engagement of semantic and syntactic processes. This study used event related potentials and time frequency analysis of EEG to identify developmental differences in neural engagement as children (ages 10-12) and adults performed an auditory verb agreement grammaticality judgment task. Adults and children revealed very few differences in comprehending grammatically correct sentences. When identifying grammatical errors, however, adults displayed widely distributed beta and theta power decreases that were significantly less pronounced in children. Adults also demonstrated a significant P600 effect, while children exhibited an apparent N400 effect. Thus, when identifying subtle grammatical errors in real time, adults display greater neural activation that is traditionally associated with syntactic processing whereas children exhibit greater activity more commonly associated with semantic processing. These findings support previous claims that the cognitive and neural underpinnings of syntactic processing are still developing in adolescence, and add to them by more clearly identifying developmental changes in the neural oscillations underlying grammatical processing.