Zheng, Jie
Permanent URI for this collectionhttps://hdl.handle.net/10735.1/6034
Jie Zheng is an associate professor of chemistry and biochemistry and serves as the head of the Zheng Lab. His research is focused on "investigating fundamental structure-property relationships of noble metals on the nano scale and applying new functional nanoparticles in biomedical imaging and nanocatalysis." His interests include:
- Nanomaterial synthesis,
- Single-molecule microscopy and
- Bioimaging.
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Item Activity and Pharmacology of Homemade Silver Nanoparticles in Refractory Metastatic Head and Neck Squamous Cell Cancer(Wiley, 2018-12-11) Singh, Jasmine; Moore, William; Fattah, Farjana; Jiang, Xingya; Zheng, Jie; Kurian, Pamela; Beg, Muhammad S.; Khan, Saad A.; 0000-0001-8546-1882 (Zheng, J); 22147423113244881679 (Zheng, J); Jiang, Xingya; Zheng, JieBackground Silver nanoparticles (AgNP) show efficacy in cancer cell lines. We present the first in-human outcome of AgNP in a cancer patient. Methods Homemade AgNP solution is manufactured using online instructions by a 78-year old male. He started consuming AgNP while on hospice after he developed nasal cavity squamous cell cancer metastatic to liver and lung. Results Electron microscopy of AgNP solution revealed bimodal nanoparticle size distribution: 3 and 12 nm. Inductively coupled plasma mass spectrometry showed basal silver ion concentrations of 32 ng/g, rising to 46 ng/g 1 hour after ingesting 60 mL of AgNP solution. Urine showed no AgNP. No toxicities were observed and he had complete radiographic resolution of his cancer. He remains without evidence of cancer 18 months later. Conclusions AgNP ingestion was associated with sustained radiographic resolution of cancer. Further testing of AgNP should be done to confirm its efficacy in head and neck cancer.Item Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles(Wiley-VCH Verlag, 2019-05-14) Peng, Chuanqi; Xu, Jing; Yu, Mengxiao; Ning, Xuhui; Huang, Yingyu; Du, Bujie; Hernandez, E.; Kapur, P.; Hsieh, J. -T; Zheng, Jie; 0000-0001-8546-1882 (Zheng, J); 22147423113244881679 (Zheng, J); Peng, Chuanqi; Xu, Jing; Yu, Mengxiao; Ning, Xuhui; Huang, Yingyu; Du, Bujie; Zheng, JiePrecise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting-clearance and permeation-retention paradoxes in the anticancer-drug delivery. Herein, we systematically investigated how renal-clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal-clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal-clearable AuNPs also accelerated body clearance of off-target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimItem Photoacoustic Imaging of Nanoparticle Transport in the Kidneys at High Temporal Resolution(Wiley-VCH Verlag) Jiang, Xingya; Du, Bujie; Tang, Shaoheng; Hsieh, J. -T; Zheng, Jie; 0000-0001-8546-1882 (Zheng, J); 22147423113244881679 (Zheng, J); Jiang, Xingya; Du, Bujie; Tang, Shaoheng; Zheng, JieNoninvasive monitoring of kidney elimination of engineered nanoparticles at high temporal and spatial resolution will not only significantly advance our fundamental understandings of nephrology on the nanoscale, but also aid in the early detection of kidney disease, which affects more than 10 % of the worldwide population. Taking advantage of strong NIR absorption of the well-defined Au₂₅(SG)₁₈ nanocluster, photoacoustic (PA) imaging was used to visualize its transport in situ through the aorta to the renal parenchyma and its subsequent filtration into the renal pelvis at a temporal resolution down to 1 s. High temporal and spatial resolution imaging of Au₂₅(SG)₁₈ kidney elimination allowed the accurate quantification of the glomerular filtration rate (GFR) of individual kidneys in normal and pathological conditions, broadening the biomedical applications of engineered nanoparticles in preclinical kidney research. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimItem Transport and Interactions of Nanoparticles in the Kidneys(Nature Publishing Group) Du, Bujie; Yu, Mengxiao; Zheng, Jie; Du, Bujie; Yu, Mengxiao; Zheng, JieKidneys are a major organ for blood filtration and waste elimination and thus play a key role in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with different kidney compartments can be precisely regulated by modulating their size, shape and surface chemistry. The quantitative understanding of nanoparticle–kidney interactions at the molecular level is important for improving disease targeting, precisely controlling nanoparticle transport and clearance, and minimizing the potential health hazards of nanomedicines. In this Review, we summarize the glomerular filtration of macromolecules and nanoparticles in the kidney and survey kidney imaging techniques for the study of nanoparticle–kidney interactions ex vivo and in vivo. We investigate the different transport mechanisms of nanoparticles in the kidneys and discuss size, charge and shape dependencies in renal clearance. Nanoparticles are then investigated for the preclinical and clinical detection and treatment of diseases such as kidney dysfunction and cancer. Finally, challenges and opportunities for renal-clearable nanoparticles are highlighted. © 2018, Springer Nature Limited.Item Physiological Stability and Renal Clearance of Ultrasmall Zwitterionic Gold Nanoparticles: Ligand Length Matters(American Institute of Physics, 2017-03-15) Ning, Xuhui; Peng, Chuanqi; Li, Eric S.; Xu, Jing; Vinluan, III,Rodrigo D.; Yu, Mengxiao; Zheng, Jie; 0000-0001-8546-1882 (Zheng, J); 22147423113244881679 (Zheng, J); Ning, Xuhui; Peng, Chuanqi; Li, Eric S.; Xu, Jing; Vinluan, III,Rodrigo D.; Yu, Mengxiao; Zheng, JieEfficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such efficient renal clearance is still not clear. Herein, we conducted head-to-head comparison on physiological stability and renal clearance of two zwitterionic luminescent AuNPs coated with cysteine and glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited similar surface charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as altered their clearance pathways. These studies indicate that the ligand length, in addition to surface charges and size, also plays a key role in the physiological stability and renal clearance of ultrasmall zwitterionic inorganic NPs.