Progress Update from the Hippocampal Subfields Group


Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. ©2019 The Authors



Cytoarchitectonics, Hippocampus (Brain), Histology, Neuroanatomy, Volume (Cubic content), Human beings

NIH grants (R01 AG‐011230, R01 AG‐055121, R01 AG‐056014, R01 AG‐034613)


CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives), ©2019 The Authors