Progress Update from the Hippocampal Subfields Group

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dc.contributor.authorOlsen, R. K.
dc.contributor.authorCarr, V. A.
dc.contributor.authorDaugherty, A. M.
dc.contributor.authorLa Joie, R.
dc.contributor.authorAmaral, R. S. C.
dc.contributor.authorAmunts, K.
dc.contributor.authorAugustinack, J. C.
dc.contributor.authorKennedy, Kristen M.
dc.contributor.authorRodrigue, Karen M.
dc.contributor.authorHippocampal Subfields Group
dc.contributor.utdAuthorKennedy, Kristen M.
dc.contributor.utdAuthorRodrigue, Karen M.
dc.date.accessioned2020-03-25T20:23:54Z
dc.date.available2020-03-25T20:23:54Z
dc.date.issued2019-06-13
dc.description.abstractIntroduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. ©2019 The Authors
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.departmentCenter for Vital Longevity
dc.description.sponsorshipNIH grants (R01 AG‐011230, R01 AG‐055121, R01 AG‐056014, R01 AG‐034613)
dc.identifier.bibliographicCitationOlsen, R. K., V. A. Carr, A. M. Daugherty, R. La Joie, et al. 2019. "Progress update from the hippocampal subfields group." Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 11(1): 439-449, doi: 10.1016/j.dadm.2019.04.001
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttp://dx.doi.org/10.1016/j.dadm.2019.04.001
dc.identifier.urihttps://hdl.handle.net/10735.1/7491
dc.identifier.volume11
dc.language.isoen
dc.publisherElsevier Inc.
dc.rightsCC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives)
dc.rights©2019 The Authors
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source.journalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
dc.subjectCytoarchitectonics
dc.subjectHippocampus (Brain)
dc.subjectHistology
dc.subjectNeuroanatomy
dc.subjectVolume (Cubic content)
dc.subjectHuman beings
dc.subject.meshHumans
dc.subject.meshNeuroimaging
dc.titleProgress Update from the Hippocampal Subfields Group
dc.type.genrearticle

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