A Drug Delivery Approach Using Zeolitic Imidazole Framework-8 and Biodegradable Polymer Composite



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Zeolitic imidazole frameworks (ZIF)-8 and polymers are potential platforms for drug delivery purpose. In this thesis these two drug delivery platforms have been combined to develop two types of drug delivery tools. To develop the first tool, model drug Cy5 dye and smURF protein have been loaded in ZIF-8 by biomineralization reaction and further encapsulated in biodegradable 50:50 ratio of poly (lactic-co-glycolic acid) polymer (PLGA) by solvent evaporation technique. This ZIF-8-PLGA polymer composite can be a promising tool to deliver a drug into the body over the course of long time slowly releasing it intact and protecting it from the environmental stressors. The second tool is the polymeric microneedles developed by using Fused Deposition Modelling based 3D printing. Poly Lactic acid was used to prepare microneedles patches. Model drug FITC Azide was loaded in ZIF-8 and further microneedles patches were loaded with those FITC containing ZIF-8 by biomineralization reaction at room temperature. Both drug delivery tools can be a robust platform to deliver drug and protein molecules by giving them protection from environmental stresses.



Drug delivery systems, Drug delivery devices, Polylactic acid, Three-dimensional printing