A Drug Delivery Approach Using Zeolitic Imidazole Framework-8 and Biodegradable Polymer Composite

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dc.contributor.advisorGassensmith, Jeremiah
dc.contributor.advisorSmaldone, Ronald A.
dc.creatorFaisal, Tahmid
dc.creator.orcid0000-0002-5523-407X
dc.date.accessioned2022-10-12T22:19:36Z
dc.date.available2022-10-12T22:19:36Z
dc.date.created2020-08
dc.date.issued2020-07-22
dc.date.submittedAugust 2020
dc.date.updated2022-10-12T22:19:37Z
dc.description.abstractZeolitic imidazole frameworks (ZIF)-8 and polymers are potential platforms for drug delivery purpose. In this thesis these two drug delivery platforms have been combined to develop two types of drug delivery tools. To develop the first tool, model drug Cy5 dye and smURF protein have been loaded in ZIF-8 by biomineralization reaction and further encapsulated in biodegradable 50:50 ratio of poly (lactic-co-glycolic acid) polymer (PLGA) by solvent evaporation technique. This ZIF-8-PLGA polymer composite can be a promising tool to deliver a drug into the body over the course of long time slowly releasing it intact and protecting it from the environmental stressors. The second tool is the polymeric microneedles developed by using Fused Deposition Modelling based 3D printing. Poly Lactic acid was used to prepare microneedles patches. Model drug FITC Azide was loaded in ZIF-8 and further microneedles patches were loaded with those FITC containing ZIF-8 by biomineralization reaction at room temperature. Both drug delivery tools can be a robust platform to deliver drug and protein molecules by giving them protection from environmental stresses.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10735.1/9510
dc.language.isoen
dc.subjectDrug delivery systems
dc.subjectDrug delivery devices
dc.subjectPolylactic acid
dc.subjectThree-dimensional printing
dc.titleA Drug Delivery Approach Using Zeolitic Imidazole Framework-8 and Biodegradable Polymer Composite
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentChemistry
thesis.degree.grantorThe University of Texas at Dallas
thesis.degree.levelMasters
thesis.degree.nameMS

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