A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI

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dc.contributor.authorSong, Boen_US
dc.contributor.authorWu, Yunkouen_US
dc.contributor.authorYu, Mengxiaoen_US
dc.contributor.authorZhao, Piyuen_US
dc.contributor.authorZhou, Chenen_US
dc.contributor.authorKiefer, Garry E.en_US
dc.contributor.authorSherry, A. Deanen_US
dc.contributor.utdAuthorSherry, A. Deanen_US
dc.date.accessioned2014-08-22T21:14:34Z
dc.date.available2014-08-22T21:14:34Z
dc.date.created2013-04-04en_US
dc.date.issued2013-04-04en_US
dc.descriptionIncludes supplementary material.en_US
dc.description.abstractA europium(Ⅲ) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ~3 ppm shift in the position of the Eu(Ⅲ)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.;en_US
dc.identifier.bibliographicCitationSong, Bo, Yunkou Wu, Mengxiao Yu, Piyu Zhao, et al. 2013. "A europium(Ⅲ)-based PARACEST agent for sensing singlet oxygen by MRI." Dalton Transactions 42(22): 8066-8069en_US
dc.identifier.issn1477-9234en_US
dc.identifier.issue22en_US
dc.identifier.startpage8066en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3918
dc.identifier.volume42en_US
dc.relation.urihttp://dx.doi.org/10.1039/C3DT50194A
dc.rights©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.en_US
dc.sourceDalton Transactions
dc.subjectActive oxygenen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectChemical Exchange Saturation Transfer (CEST)en_US
dc.titleA Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRIen_US
dc.type.genreArticleen_US

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