Emerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery

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dc.contributor.ORCID0000-0002-3768-6996 (Campbell, ZT)
dc.contributor.ORCID0000-0002-6971-6221 (Price, TJ)
dc.contributor.ORCID0000-0001-8276-3690 (Pancrazio, JJ)
dc.contributor.authorBlack, Bryan J.
dc.contributor.authorAtmaramani, Rahul
dc.contributor.authorPlagens, Sarah
dc.contributor.authorCampbell, Zachary T.
dc.contributor.authorDussor, Gregory
dc.contributor.authorPrice, Theodore J.
dc.contributor.authorPancrazio, Joseph J.
dc.contributor.utdAuthorBlack, Bryan J.
dc.contributor.utdAuthorAtmaramani, Rahul
dc.contributor.utdAuthorPlagens, Sarah
dc.contributor.utdAuthorCampbell, Zachary T.
dc.contributor.utdAuthorDussor, Gregory
dc.contributor.utdAuthorPrice, Theodore J.
dc.contributor.utdAuthorPancrazio, Joseph J.
dc.date.accessioned2020-09-20T15:24:20Z
dc.date.available2020-09-20T15:24:20Z
dc.date.issued2018-11-13
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.description.abstractThe tolerance, abuse, and potential exacerbation associated with classical chronic pain medications such as opioids creates a need for alternative therapeutics. Phenotypic screening provides a complementary approach to traditional target-based drug discovery. Profiling cellular phenotypes enables quantification of physiologically relevant traits central to a disease pathology without prior identification of a specific drug target. For complex disorders such as chronic pain, which likely involves many molecular targets, this approach may identify novel treatments. Sensory neurons, termed nociceptors, are derived from dorsal root ganglia (DRG) and can undergo changes in membrane excitability during chronic pain. In this review, we describe phenotypic screening paradigms that make use of nociceptor electrophysiology. The purpose of this paper is to review the bioelectrical behavior of DRG neurons, signaling complexity in sensory neurons, various sensory neuron models, assays for bioelectrical behavior, and emerging efforts to leverage microfabrication and microfluidics for assay development. We discuss limitations and advantages of these various approaches and offer perspectives on opportunities for future development.
dc.description.departmentErik Jonsson School of Engineering and Computer Science
dc.description.departmentSchool of Behavioral and Brain Sciences
dc.description.sponsorshipNational Institutes of Health (NIH), United States, NS065926, NS102161, NS072204, and NS100788
dc.identifier.bibliographicCitationBlack, Bryan J., Rahul Atmaramani, Sarah Plagens, Zachary T. Campbell, et al. 2019. "Emerging neurotechnology for antinoceptive mechanisms and therapeutics discovery." Biosensors & Bioelectronics 126: 679-689., doi:10.1016/j.bios.2018.11.015
dc.identifier.issn0956-5663
dc.identifier.urihttps://dx.doi.org/10.1016/j.bios.2018.11.015
dc.identifier.urihttps://hdl.handle.net/10735.1/8908
dc.identifier.volume126
dc.language.isoen
dc.publisherElsevier Advanced Technology
dc.rights©2019 Elsevier
dc.source.journalBiosensors & Bioelectronics
dc.subjectNeurotechnology (Bioengineering)
dc.subjectBiosensors
dc.subjectNeuralgia
dc.subjectSensory neurons
dc.subjectSensory neurons, Primary
dc.subjectProteins—Synthesis
dc.subjectNeuroglia
dc.subjectMicroelectrodes
dc.subject.meshInduced Pluripotent Stem Cells
dc.subject.meshGanglia, Spinal
dc.titleEmerging Neurotechnology for Antinoceptive Mechanisms and Therapeutics Discovery
dc.type.genrearticle

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Pancrazio, Joseph J.
Campbell, Zachary T.
Dussor, Gregory
Price, Theodore J.