The Lifecycle of the Ebola Virus in Host Cells

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JECS-2061-8308-29.pdf (11.11 MB)

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2017-06-15

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http://hdl.handle.net/10735.1/6085

Abstract

Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle. Furthermore, the review outlines the aspects remain unclear that urgently need to be solved in future research.

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Keywords

Crystals--Structure, Ebola virus disease, VP30 protein, EBOV, Folate Receptor 1, Marburgvirus, VP40 protein, virus, Niemann-Pick Disease, Type C, Phosphatidylserine receptors, Cell Membrane, Glycoproteins, Viral Matrix Proteins, Plasma Membranes

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"This work was supported by grants from the Major Program of National Natural Science Foundation of China (#81590763), and the Science & Technology Key Program of Zhejiang China (#2014C03001-2/3)."

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CC BY 3.0 (Attribution), ©2017 The Authors

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