The Lifecycle of the Ebola Virus in Host Cells

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dc.contributor.authorYu, Dong-Shanen_US
dc.contributor.authorWeng, Tian-Haoen_US
dc.contributor.authorWu, Xiao-Xinen_US
dc.contributor.authorWang, Frederick X. C.en_US
dc.contributor.authorLu, Xiang-Yunen_US
dc.contributor.authorWu, Hai-Boen_US
dc.contributor.authorWu, Nan-Pingen_US
dc.contributor.authorLi, Lan-Juanen_US
dc.contributor.authorYao, Hang-Pingen_US
dc.contributor.utdAuthorWang, Frederick X. C.en_US
dc.date.accessioned2018-09-24T15:02:54Z
dc.date.available2018-09-24T15:02:54Z
dc.date.created2017-06-15
dc.date.issued2017-06-15en_US
dc.description.abstractEbola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle. Furthermore, the review outlines the aspects remain unclear that urgently need to be solved in future research.en_US
dc.description.departmentErik Jonsson School of Engineering and Computer Scienceen_US
dc.description.sponsorship"This work was supported by grants from the Major Program of National Natural Science Foundation of China (#81590763), and the Science & Technology Key Program of Zhejiang China (#2014C03001-2/3)."en_US
dc.identifier.bibliographicCitationYu, Dong-Shan, Tian-Hao Weng, Xiao-Xin Wu, Frederick X. C. Wang, et al. 2017. "The lifecycle of the Ebola virus in host cells." 8(33): 55750-55759.
dc.identifier.issn1949-2553en_US
dc.identifier.issue33en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6085
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights©2017 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.source.journalOncotargeten_US
dc.subjectCrystals--Structureen_US
dc.subjectEbola virus diseaseen_US
dc.subjectVP30 protein, EBOVen_US
dc.subjectFolate Receptor 1en_US
dc.subjectMarburgvirusen_US
dc.subjectVP40 protein, virusen_US
dc.subjectNiemann-Pick Disease, Type Cen_US
dc.subjectPhosphatidylserine receptorsen_US
dc.subjectCell Membraneen_US
dc.subjectGlycoproteinsen_US
dc.subjectViral Matrix Proteinsen_US
dc.subjectPlasma Membranesen_US
dc.titleThe Lifecycle of the Ebola Virus in Host Cellsen_US
dc.type.genrearticleen_US

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