Physiological Stability and Renal Clearance of Ultrasmall Zwitterionic Gold Nanoparticles: Ligand Length Matters

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dc.contributor.ORCID0000-0001-8546-1882 (Zheng, J)en_US
dc.contributor.VIAF22147423113244881679 (Zheng, J)en_US
dc.contributor.authorNing, Xuhuien_US
dc.contributor.authorPeng, Chuanqien_US
dc.contributor.authorLi, Eric S.en_US
dc.contributor.authorXu, Jingen_US
dc.contributor.authorVinluan, III,Rodrigo D.en_US
dc.contributor.authorYu, Mengxiaoen_US
dc.contributor.authorZheng, Jieen_US
dc.contributor.utdAuthorNing, Xuhuien_US
dc.contributor.utdAuthorPeng, Chuanqien_US
dc.contributor.utdAuthorLi, Eric S.en_US
dc.contributor.utdAuthorXu, Jingen_US
dc.contributor.utdAuthorVinluan, III,Rodrigo D.en_US
dc.contributor.utdAuthorYu, Mengxiaoen_US
dc.contributor.utdAuthorZheng, Jieen_US
dc.date.accessioned2018-08-31T15:03:00Z
dc.date.available2018-08-31T15:03:00Z
dc.date.created2017-03-15
dc.date.issued2017-03-15en_US
dc.description.abstractEfficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney functional imaging. However, origin of such efficient renal clearance is still not clear. Herein, we conducted head-to-head comparison on physiological stability and renal clearance of two zwitterionic luminescent AuNPs coated with cysteine and glycine-cysteine (Cys-AuNPs and Gly-Cys-AuNPs), respectively. While both of them exhibited similar surface charges and the same core sizes, additional glycine slightly increased the hydrodynamic diameter of the AuNPs by 0.4 nm but significantly enhanced physiological stability of the AuNPs as well as altered their clearance pathways. These studies indicate that the ligand length, in addition to surface charges and size, also plays a key role in the physiological stability and renal clearance of ultrasmall zwitterionic inorganic NPs.en_US
dc.description.departmentSchool of Natural Sciences and Mathematicsen_US
dc.description.sponsorshipCPRIT (Nos. PR140544 and RP160866); NIH (No. 1R01DK103363).en_US
dc.identifier.bibliographicCitationNing, Xuhui, Chuanqi Peng, Eric S. Li, Jing Xu, et al. 2017. "Physiological stability and renal clearance of ultrasmall zwitterionic gold nanoparticles: Ligand length matters." APL Materials 5(5), doi:10.1063/1.4978381en_US
dc.identifier.issn2166-532Xen_US
dc.identifier.issue5en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/6048
dc.identifier.volume5en_US
dc.publisherAmerican Institute of Physicsen_US
dc.relation.urihttp://dx.doi.org/10.1063/1.4978381
dc.rightsCC BY 4.0 (Attribution)en_US
dc.rights©2017 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceAPL Materials
dc.subjectGlutathioneen_US
dc.subjectLigandsen_US
dc.subjectGolden_US
dc.subjectCysteineen_US
dc.subjectNanoparticlesen_US
dc.subjectFluorescenceen_US
dc.subjectMetal coatingen_US
dc.subjectPolyelectrolytesen_US
dc.subjectHydrodynamicsen_US
dc.subjectKidneysen_US
dc.subjectLiveren_US
dc.subjectProteinsen_US
dc.titlePhysiological Stability and Renal Clearance of Ultrasmall Zwitterionic Gold Nanoparticles: Ligand Length Mattersen_US
dc.type.genrearticleen_US

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