Biocompatible Organic Charge Transfer Complex Nanoparticles Based on a Semi-Crystalline Cellulose Template

Date

2015-06-19

ORCID

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

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Abstract

Using a bio-inspired cellulose template, new charge transfer (CT) nanoparticles (NPs) with unique and intriguing emission properties are reported. Pyrene-modified 2,3-di-O-methyl cellulose formed CT complexes with small molecule acceptors, e.g. 7,7,8,8-tetracyanoquinodimethane (TCNQ), and exhibited aggregation-induced emission (AIE) in aqueous medium upon nanoparticle formation. The TCNQ-CT NPs showed multicolor fluorescence emissions at 370-400 nm, 602 nm and 777 nm, when excited at 330 nm, 485 nm and 620 nm respectively. The cellulose-TCNQ NPs are biocompatible and demonstrate an advance in the use of the CT mechanism for biomedical imaging applications both in vitro and in vivo.

Description

Includes correction published 2015-11-10

Keywords

Tetracyanoquinodimethane, Cellulose, Methane, Nanoparticles, Pyrene (Chemical), Unclassified drug, Absorption, Animals--Experiments, Biocompatibility, Confocal microscopy, Esterification, Fluorescence, Gel permeation chromatography, Infrared spectroscopy, Melanoma, Molecular weights, Nuclear magnetic resonance, Photoluminescence, Thermogravimetry

item.page.sponsorship

"D.J.S. acknowledges grant support from the Cancer Prevention and Research Institute of Texas (CPRIT) (R1212) and the Welch Foundation (I-1855). J.B.M. acknowledges fellowship support from CPRIT (RP140110). M.C.S. acknowledges grant support from the Welch Foundation (AT-1740), the NSF (Career DMR-0956116), and the NSF-MRI (CHE-1126177)."

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©2015 The Royal Society of Chemistry. This article may not be further made available or distributed.

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