A Novel Class of Polymeric pH-Responsive MRI CEST Agents

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dc.contributor.authorZhang, Shanrongen_US
dc.contributor.authorZhou, K.en_US
dc.contributor.authorHuang, G.en_US
dc.contributor.authorTakahashi, Masayaen_US
dc.contributor.authorSherry, A. Deanen_US
dc.contributor.authorGao, Jinmingen_US
dc.contributor.utdAuthorSherry, A. Deanen_US
dc.date.accessioned2014-08-29T22:23:35Z
dc.date.available2014-08-29T22:23:35Z
dc.date.created2013-05-26en_US
dc.date.issued2013-05-26en_US
dc.description.abstractIn this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.en_US
dc.identifier.bibliographicCitationZhang, S., K. Zhou, G. Huang, M. Takahashi, et al. 2013. "A novel class of polymeric pH-responsive MRI CEST agents." Chemical Communications 49(57): 6418-6420en_US
dc.identifier.issn1359-7345en_US
dc.identifier.issue57en_US
dc.identifier.startpage6418en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/3947
dc.identifier.volume49en_US
dc.language.isoenen_US
dc.relation.urihttp://dx.doi.org/10.1039/C3CC42452A
dc.rights©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.en_US
dc.sourceChemical Communications
dc.subjectChemical Exchange Saturation Transfer (CEST)en_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectBlock copolymersen_US
dc.subjectMicellesen_US
dc.titleA Novel Class of Polymeric pH-Responsive MRI CEST Agentsen_US
dc.type.genreArticleen_US

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