DNA Looping in Topologically Constrained Domains

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dc.contributor.authorBharadwaj, Anushaen_US
dc.contributor.authorKesinger, Matthew R.en_US
dc.contributor.authorShoura, Massa J.en_US
dc.contributor.authorVetcher, Alexandreen_US
dc.contributor.authorLevene, Stephen D.en_US
dc.contributor.utdAuthorBharadwaj, Anushaen_US
dc.contributor.utdAuthorKesinger, Matthew R.en_US
dc.contributor.utdAuthorShoura, Massa J.en_US
dc.contributor.utdAuthorVetcher, Alexandreen_US
dc.contributor.utdAuthorLevene, Stephen D.en_US
dc.date.accessioned2012-06-19T22:10:51Z
dc.date.available2012-06-19T22:10:51Z
dc.date.created2012-05-15en_US
dc.date.issued2012-05-15
dc.description.abstractNew techniques are needed in order to study the effects of DNA supercoiling on loop-mediated regulation. The thermodynamics of DNA looping depend periodically on the helical phasing between recognition sites. A long-term goal is to provide enabling technologies for ensemble and single-molecule FRET studies of DNA looping mediated by lac repressor in vitro and in vivo. Other applications of the methodology include engineering of DNA substrates for studies of site-specific recombination and other enzyme systemsen_US
dc.description.sponsorshipThis work was supported by grants from the DMS/NIGMS Joint Program in Mathematical Biology (GM67242 and DMS-800929).
dc.identifier.bibliographicCitationShoura, M. J., A. A. Vetcher, S. M. Giovan, F. Bardai, A. Bharadwaj, M. R. Kesinger, and S. D. Levene. 2012. "Measurements of DNA-Loop Formation Via Cre-Mediated Recombination." Nucleic Acids Research 40 (15): 7452-7464.en_US
dc.identifier.urihttp://hdl.handle.net/10735.1/2140
dc.publisherOxford University Press.
dc.relation.urihttp://dx.doi.org/10.1093/nar/gks430
dc.rightsCC BY-NC 3.0 (Attribution-NonCommercial)en_US
dc.rights©2012 The Authorsen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceNucleic Acids Research
dc.subjectDNA
dc.subjectFluorescence resonance energy transfer
dc.subjectRecombination, genetic
dc.subjectDNA-protein interactions
dc.titleDNA Looping in Topologically Constrained Domainsen_US
dc.typeTexten_US
dc.type.genreArticle
dc.type.genrePresentationen_US

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Levene, Stephen D.