Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles

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dc.contributor.ORCID0000-0001-8546-1882 (Zheng, J)
dc.contributor.VIAF22147423113244881679 (Zheng, J)
dc.contributor.authorPeng, Chuanqi
dc.contributor.authorXu, Jing
dc.contributor.authorYu, Mengxiao
dc.contributor.authorNing, Xuhui
dc.contributor.authorHuang, Yingyu
dc.contributor.authorDu, Bujie
dc.contributor.authorHernandez, E.
dc.contributor.authorKapur, P.
dc.contributor.authorHsieh, J. -T
dc.contributor.authorZheng, Jie
dc.contributor.utdAuthorPeng, Chuanqi
dc.contributor.utdAuthorXu, Jing
dc.contributor.utdAuthorYu, Mengxiao
dc.contributor.utdAuthorNing, Xuhui
dc.contributor.utdAuthorHuang, Yingyu
dc.contributor.utdAuthorDu, Bujie
dc.contributor.utdAuthorZheng, Jie
dc.date.accessioned2020-02-25T17:59:44Z
dc.date.available2020-02-25T17:59:44Z
dc.date.issued2019-05-14
dc.descriptionDue to copyright restrictions and/or publisher's policy full text access from Treasures at UT Dallas is limited to current UTD affiliates (use the provided Link to Article).
dc.descriptionSupplementary material is available on publisher's website.
dc.description.abstractPrecise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting-clearance and permeation-retention paradoxes in the anticancer-drug delivery. Herein, we systematically investigated how renal-clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal-clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal-clearable AuNPs also accelerated body clearance of off-target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.description.departmentSchool of Natural Sciences and Mathematics
dc.description.sponsorshipNIH (1R01DK103363), CPRIT (RP160866), and Welch Research Foundation (AT‐1974‐20180324)
dc.identifier.bibliographicCitationPeng, C., J. Xu, M. Yu, X. Ning, et al. 2019. "Tuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles." Angewandte Chemie - International Edition 58(25): 8479-8483, doi: 10.1002/anie.201903256
dc.identifier.issn1433-7851
dc.identifier.issue25
dc.identifier.urihttp://dx.doi.org/10.1002/anie.201903256
dc.identifier.urihttps://hdl.handle.net/10735.1/7299
dc.identifier.volume58
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.rights©2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
dc.source.journalAngewandte Chemie - International Edition
dc.subjectDrug delivery systems
dc.subjectTumors
dc.subjectOptical fiber detectors
dc.subjectHistology
dc.subjectNanoparticles
dc.subjectTissues--Cancer
dc.subjectBlood-vessels--Permeability
dc.titleTuning the In Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles
dc.type.genrearticle

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