Genome Wide Mapping of Foxo1 Binding-Sites in Murine T Lymphocytes




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Elsevier Inc


The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well characterized. In this study, we focused on mapping the genome wide Foxo1-binding sites in naïve CD4(+) T cells, CD8(+) T cells, and Foxp3(+) regulatory T (Treg) cells. By using chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq), we identified Foxo1 binding sites that were shared among or specific to the three T cell populations. Here we describe the experiments, quality controls, as well as the deep sequencing data. Part of the data analysis has been published by Ouyang W et al. in Nature 20121] and Kim MV et al. in Immunity 20132], and the associated data set were uploaded to NCBI Gene Expression Omnibus.;



T-Lymphocytes, Foxo1 protein, mouse, Genomes, Foxp3 protein, mouse, birA protein

US National Institutes of Health (R01 AI102888/AI/NIAID)


CC BY-NC-ND 3.0 (Attribution-NonCommercial-NoDerivatives), ©2014 The Authors