A Novel Class of Polymeric pH-Responsive MRI CEST Agents
Date
2013-05-26
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Abstract
In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.
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Chemical Exchange Saturation Transfer (CEST), Magnetic resonance imaging, Block copolymers, Micelles
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©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.